Chinese Journal of Organic Chemistry ›› 2020, Vol. 40 ›› Issue (4): 817-830.DOI: 10.6023/cjoc201910029 Previous Articles     Next Articles

苯并富烯合成方法研究进展

史传星a,b, 冯陈国b,c, 陈雅丽a, 张曙盛b,c, 林国强b   

  1. a 上海大学理学院 上海 200444;
    b 中国科学院上海有机化学研究所 天然产物有机合成化学重点实验室 上海 200032;
    c 上海中医药大学 创新中药研究院 上海 201203
  • 收稿日期:2019-10-25 修回日期:2019-12-17 出版日期:2020-04-25 发布日期:2020-01-03
  • 通讯作者: 陈雅丽, 张曙盛 E-mail:ylchen@staff.shu.edu.cn;zhangss@sioc.ac.cn
  • 基金资助:
    国家自然科学基金(Nos.221572253,21772216)、中国科学院战略性先导科技专项(No.XDB20020100)、中国科学院前沿科学重点研究(No.QYZDYSSWSLH026)资助项目.

Recent Advancement in Benzofulvene Synthesis

Shi Chuanxinga,b, Feng Chenguob,c, Chen Yalia, Zhang Shushengb,c, Lin Guoqiangb   

  1. a College of Sciences, Shanghai University, Shanghai 200444;
    b CAS Key Laboratory of Synthetic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032;
    c Innovation Research Instutute of Tranditional Chinese Medicine, Shanghai University of Tranditional Chinese Medicine, Shanghai 201203
  • Received:2019-10-25 Revised:2019-12-17 Online:2020-04-25 Published:2020-01-03
  • Supported by:
    Project supported by the National Natural Science Foundation of China (Nos. 21572253, 21772216), the Strategic Priority Research Program of the Chinese Academy of Sciences (No. XDB 20020100), and the Key Research Program of Frontier Science (No. QYZDY-SSWSLH026).

Benzofulvenes were widely found in natural products and bioactive molecules, and also served as important building blocks in material science and transition-metal chemistry. Great efforts have been devoted to the efficient synthesis of these interesting molecules, and rapid advancement has been made in the past two decades. According to the types of the initiation of the reaction, these methods can roughly be classified into five categories:thermal or photochemical cyclization of enyne-al-lenes or enediynes, transition metal-catalyzed sequential cyclization reaction, electrophilic or nucleophilic attack initiated cyclization, radical initiated cyclization and acid promoted cyclization. This review describes the important synthetic methods of benzofulvenes according to their reaction types.

Key words: benzofulvenes, transition metal catalysis, radical, C—H bond activation, cyclization reaction