Chinese Journal of Organic Chemistry ›› 2020, Vol. 40 ›› Issue (10): 3177-3195.DOI: 10.6023/cjoc202005016 Previous Articles     Next Articles


秦文兵, 陈嘉怡, 熊威, 刘国凯   

  1. 深圳大学医学部药学院 广东深圳 518060
  • 收稿日期:2020-05-07 修回日期:2020-06-10 发布日期:2020-06-28
  • 通讯作者: 刘国凯
  • 基金资助:

Recent Advance in Development and Application of Electrophilic Difluoromethylating Reagents

Qin Wenbing, Chen Jiayi, Xiong Wei, Liu Guokai   

  1. School of Pharmaceutical Sciences, Shenzhen University Health Science Center, Shenzhen, Guangdong 518060
  • Received:2020-05-07 Revised:2020-06-10 Published:2020-06-28
  • Supported by:
    Project supported by the Natural Science Foundation of Shenzhen City (Nos. KQJSCX20180328095508144) and the Natural Science Foundation of Guangdong Province (No. 2020A1515010874).

In the past two decades, the development and application of bench-stable electrophilic difluoromethylating reagents have attracted considerable attention. Consequently, some progress in this area has been ongoing recently. Electrophilic difluoromethylating reagents play a very important role in the synthesis of fluorine-containing compounds, due to their capability of readily transferring difluoromethyl moiety (CF2H) into wide range of nucleophiles, as well as being used as difluoromethyl radical(•CF2H) precursorfor radical difluoromethylations. However, the electrophilic difluoromethylating reagents and application therein remain still underdeveloped in comparison with nucleophilic ones. The research advance in electrophilic difluoromethylating reagents in past two decades is reviewed.

Key words: electrophilic difluoromethylating reagent, electrophilic difluoromethylation reaction, radical difluoromethylation reaction, difluorocarbene