Chinese Journal of Organic Chemistry ›› 2020, Vol. 40 ›› Issue (11): 3794-3801.DOI: 10.6023/cjoc202005046 Previous Articles     Next Articles


许瑶, 康经武   

  1. 中国科学院上海有机化学研究所 生命有机化学国家重点实验室 上海 200032
  • 收稿日期:2020-05-18 修回日期:2020-06-29 发布日期:2020-07-17
  • 通讯作者: 康经武
  • 基金资助:

Chiral Separation by Ultrafast and Two-Dimensional Liquid Chromatography

Xu Yao, Kang Jingwu   

  1. State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Science, Shanghai 200032
  • Received:2020-05-18 Revised:2020-06-29 Published:2020-07-17
  • Supported by:
    Project supported by the National Natural Science Foundation of China (Nos. 21775158, 21375140, 21175146).

Although the chiral separation techniques represented by the polysaccharides-based chiral stationary phases are almost matured, the chiral separation for complex samples remains a challenge. To this end, two dimensional liquid chromatography has been developed rapidly. Recently, to achieve the chiral separation with two dimensional liquid chromatoraphy, the development of the ultrafast liquid chromatography has caused considerable attention. The development of ultrafast liquid chromatography and two-dimensional liquid chromatography also caters to the development of high-throughput organic synthesis technology. In this review the recent progress in the chiral separation by the ultrafast and two-dimensional liquid chromatography is summarized. This review focuses on the progress in the techniques of the chiral packing materials for ultrafast chromatography, the chiral separation strategy and its application in complex samples. Finally, the application perspective of ultra-fast and two-dimensional liquid phase in high-throughput organic synthesis techniques is prospected.

Key words: ultrafast liquid chromatography, two-dimensional liquid chromatography, chiral separation, high-throughput separation