Chinese Journal of Organic Chemistry ›› 2020, Vol. 40 ›› Issue (12): 4168-4183.DOI: 10.6023/cjoc202005074 Previous Articles     Next Articles


杨凯a,b, 姚辰b, 高娟娟c, 陈思鸿b, 郑雪洁b, 邓璐璇b, 张毓娜b, 刘美娟b, 汪朝阳b   

  1. a 赣南医学院药学院 江西赣州 341000;
    b 华南师范大学化学学院 教育部环境理论化学重点实验室 广州 510006;
    c 赣南医学院康复学院 江西赣州 341000
  • 收稿日期:2020-05-27 修回日期:2020-06-15 发布日期:2020-07-01
  • 通讯作者: 汪朝阳, 杨凯;
  • 基金资助:

Progress on the Synthesis of Pyrido[1,2-a]benzimidazoles

Yang Kaia,b, Yao Chenb, Gao Juanjuanc, Chen Sihongb, Zheng Xuejieb, Deng Luxuanb, Zhang Yu'nab, Liu Meijuanb, Wang Zhaoyangb   

  1. a College of Pharmacy, Gannan Medical University, Ganzhou, Jiangxi 341000;
    a Key Laboratory of Theoretical Chemistry of Environment, Ministry of Education, School of Chemistry, South China Normal University, Guangzhou 510006;
    c College of Sports and Rehabilitation, Gannan Medical University, Ganzhou, Jiangxi 341000
  • Received:2020-05-27 Revised:2020-06-15 Published:2020-07-01
  • Supported by:
    Project supported by the Guangdong Provincial Science and Technology Project (No. 2017A010103016), the Scientific Research Project of Gannan Medical University (No. YB201903), the Undergraduates Innovation Project of South China Normal University (No. 202003) and the Extracurricular Project for Students' Scientific Research of South China Normal University (No.19HHGB08).

Pyrido[1,2-a]benzimidazole is one of the important azaheterocycles with three fused aromatic rings. These molecules containing this skeleton have wide application prospects in the fields of medicinal chemistry and materials, and their syntheses have attracted much attention in organic chemistry. According to the retrosynthetic analysis on the construction of different rings in target molecules, the research progress on the synthesis of pyrido[1,2-a]benzimidazoles from different types of starting materials is reviewed, and its future development direction is prospected.

Key words: azaheterocycle, pyrido[1,2-a]benzimidazole, retrosynthetic analysis, metal catalysis, C-H activation, tandem reaction, 2-aminopyridine, o-phenylenediamine