Chinese Journal of Organic Chemistry ›› 2021, Vol. 41 ›› Issue (1): 52-64.DOI: 10.6023/cjoc202008003 Previous Articles     Next Articles



张振国a, 刘笑笑a, 宗鑫龙a, 苑亚林a, 刘双磊a, 张婷a, 吴子尚a, 杨静莹*(), 贾振华a,*()   

  1. a 南京工业大学化学与分子工程学院 先进化学制造研究院 南京 211816
  • 收稿日期:2020-08-05 修回日期:2020-10-13 发布日期:2020-10-22
  • 通讯作者: 杨静莹, 贾振华
  • 作者简介:
    * Corresponding authors. E-mail: ;
  • 基金资助:
    南京工业大学启动基金(38037037); 江苏省协同联合创新中心和江苏省研究生科研与实践创新计划(KYCX20_1031)

Recent Advance on the Synthesis of 3,3'-Bisindolylmethane Derivatives under Transition-Metal-Free Catalytic Conditions

Zhenguo Zhanga, Xiaoxiao Liua, Xinlong Zonga, Yalin Yuana, Shuanglei Liua, Ting Zhanga, Zishang Wua, Jingying Yang*(), Zhenhua Jiaa,*()   

  1. 1 Institute of Advanced Synthesis, School of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing 211816
  • Received:2020-08-05 Revised:2020-10-13 Published:2020-10-22
  • Contact: Jingying Yang, Zhenhua Jia
  • Supported by:
    the Start-up Grant of Nanjing Tech University(38037037); the Synergetic Innovation Center for Advanced Materials Fellowship and Postgraduate Research & Practice Innovation Program of Jiangsu Province(KYCX20_1031)

3,3'-Bisindolylmethanes (3,3'-BIMs) compounds are important indole alkyloads and their units are widely found in various natural products, functional materials and synthetic pharmaceutical compounds. Due to diverse biological activities and functionalities, for instance, antioxidant, anti-inflammatory, antiangiogenic, anti-bacterial and anti-cancer etc., the construction of 3,3'-BIMs is raised considerable concerns. Conventional methods especially focused on symmetrical 3,3'-BIMs were the condensition of indoles with carbonyl compounds via Friedel-Crafts pathway in the presence of Brønsted acids or Lewis acids. However, the utilization of transtion metals led the residue into the products and environmental contamination. The recent advance on the synthesis of 3,3'-BIMs since 2010, mainly concerned on the approaches and corresponding me- chanism to prepare symmetrical and unsymmetrical 3,3'-BIMs under transition-metal-free conditions is summarized and dis- cussed, aiming to provide important theoretical evidence and techinical support for further biological evaluations on desired compounds.

Key words: Keywords transition-metal-free, 3, 3'-bisindolylmethane, biological activity, diversity