Chinese Journal of Organic Chemistry ›› 2021, Vol. 41 ›› Issue (5): 1897-1924.DOI: 10.6023/cjoc202009053 Previous Articles     Next Articles



王浩a, 应娉b, 俞静波a,*(), 苏为科a,b   

  1. a 浙江工业大学绿色制药协同创新中心 国家化学原料药合成工程技术研究中心 杭州 310014
    b 浙江工业大学药学院 杭州 310014
  • 收稿日期:2020-09-27 修回日期:2020-11-14 发布日期:2020-12-01
  • 通讯作者: 俞静波
  • 基金资助:
    国家自然科学基金(21978270); 国家自然科学基金(21406201)

Alternative Strategies Enabling Cross-Dehydrogenative Coupling: Access to C—C Bonds

Hao Wanga, Ping Yingb, Jingbo Yua,*(), Weike Sua,b   

  1. a Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, National Engineering Research Center for Process Development of Active Pharmaceutical Ingredients, Hangzhou 310014
    b College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014
  • Received:2020-09-27 Revised:2020-11-14 Published:2020-12-01
  • Contact: Jingbo Yu
  • About author:
    * Corresponding author. E-mail:
  • Supported by:
    National Natural Science Foundation of China(21978270); National Natural Science Foundation of China(21406201)

Cross-dehydrogenative coupling (CDC) reactions have been esteemed as one of the straightforward and efficient tool for C—C bond formation. Typically, these reactions are generally realized via solvent-based thermochemistry, using a round bottom flask and a magnetic or mechanical stirrer. With the development of new synthetic strategies, alternative technologies currently available in laboratories that facilitate CDC reactions, such as photochemistry, electrochemistry and mechanochemistry have arisen rapidly, providing green and high efficiency strategies for the construction of C—C bonds which are perfect complement to traditional thermochemistry. In order to compare the advantages of each approaches more clearly, and promote the development of CDC reactions, CDC reactions related to two or more enabling technologies of same or similar substrates are reviewed, hoping to provide help for the development of CDC reaction and the development of new organic synthesis methods.

Key words: cross-dehydrogenative coupling, thermochemistry, photochemistry, electrochemistry, mechanochemistry