Chinese Journal of Organic Chemistry ›› 2021, Vol. 41 ›› Issue (6): 2217-2227.DOI: 10.6023/cjoc202012053 Previous Articles     Next Articles



严锡飞a, 郑剑峰a,*(), 李卫东a,b,*()   

  1. a 西南交通大学生命科学与工程学院 四川省天然药物仿生合成工程研究中心 成都 610031
    b 伊犁师范大学 新疆天然产物化学与应用重点实验室 新疆伊宁 835000
  • 收稿日期:2020-12-31 修回日期:2021-01-26 发布日期:2021-02-26
  • 通讯作者: 郑剑峰, 李卫东
  • 基金资助:
    国家自然科学基金(21901215); 国家自然科学基金(21672030); 中央高校基本科研业务费专项资金(2682020CX53)

Studies on the Chemical Synthesis of Natural Drugs Berberine

Xifei Yana, Jianfeng Zhenga(), Wei-Dong Z. Lia,b()   

  1. a Sichuan Engineering Research Center for Biomimetic Synthesis of Natural Drugs, School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031
    b Key Laboratory of Natural Product Chemistry and Application in Xinjiang, Yili Normal University, Yining, Xinjiang 835000
  • Received:2020-12-31 Revised:2021-01-26 Published:2021-02-26
  • Contact: Jianfeng Zheng, Wei-Dong Z. Li
  • Supported by:
    National Natural Science Foundation of China(21901215); National Natural Science Foundation of China(21672030); Fundamental Research Funds for the Central Universities(2682020CX53); Key Program of Natural Science Foundation of Xinjiang Autonomous Region Colleges(XJEDU2018I018)

Berberine is an important natural drug and a kind of benzyl isoquinoline alkaloid, which has unique four-ring structure. In recent years, pharmacological research has found berberine is expected to be used in the clinical treatment of cancer, diabetes and other frequently occurring diseases. Based on the Woodward’s biosynthetic hypothesis, a schematic review on the synthetic studies towards berberine is provided.

Key words: natural drug, berberine, benzyl isoquinoline, total synthesis