Chinese Journal of Organic Chemistry ›› 2021, Vol. 41 ›› Issue (11): 4255-4278.DOI: 10.6023/cjoc202103044 Previous Articles     Next Articles



曾尾女, 黄国雷, 王斌, 蔡瑾, 郑彩娟*()   

  1. 海南师范大学化学与化工学院 热带药用资源化学教育部重点实验南省热带药用植物化学重点实验室 海口 571158
  • 收稿日期:2021-03-24 修回日期:2021-06-14 发布日期:2021-07-12
  • 通讯作者: 郑彩娟
  • 基金资助:
    国家自然科学基金(31760093); 海南省自然科学基金(220RC593); 海南省自然科学基金(218MS045); 海南省重点科技计划(ZDYF2019183)

Secondary Metabolites and Bioactivities of Penicillium sp. Sourced from Mangrove from 2007 to 2020

Weinü Zeng, Guolei Huang, Bin Wang, Jin Cai, Caijuan Zheng()   

  1. Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, Key Laboratory of Tropical Medicinal Resources Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158
  • Received:2021-03-24 Revised:2021-06-14 Published:2021-07-12
  • Contact: Caijuan Zheng
  • Supported by:
    National Natural Science Foundation of China(31760093); Natural Science Foundation of Hainan Province(220RC593); Natural Science Foundation of Hainan Province(218MS045); Key Research and Development Program of Hainan Province(ZDYF2019183)

Mangrove plants grow in tropical and subtropical intertidal zones with acid, salt and oxygen deficit. The particularity of the growth environment provides a special host environment for mangrove fungi. The unique genetic background and metabolic pathway of mangrove-derived fungi make their secondary metabolites have novel structures and diverse biological activities. The genus of Penicillium is widely distributed, which is a large group of mangrove-derived fungi. It can produce metabolites with various structural types and novel structures such as alkaloids, peptides, terpenes, polyketones and other metabolites. Most of them have anti-tumor, anti-inflammatory, anti-bacterial, enzyme inhibitors and other bioactivities. The advances of the 276 natural products produced from mangrove-derived Penicillium in recent 14 years (from 2007 to 2020) are reviewed, in order to provide reference for the development of new natural drugs of mangrove Penicillium sp. fungi.

Key words: mangrove, Penicillium sp., secondary metabolite, bioactivity