Chinese Journal of Organic Chemistry ›› 2022, Vol. 42 ›› Issue (4): 925-944.DOI: 10.6023/cjoc202109020 Previous Articles     Next Articles



姚婷, 李佳燕, 王佳明, 赵常贵*()   

  1. 北京师范大学化学学院 放射性药物教育部重点实验室 北京 100875
  • 收稿日期:2021-09-14 修回日期:2021-11-16 发布日期:2021-12-02
  • 通讯作者: 赵常贵
  • 基金资助:
    北京市自然科学基金(2212009); 国家自然科学基金(22171027); 北京师范大学启动经费(312232112)

Recent Advances for the Construction of Seven-Membered Ring Catalyzed by N-Heterocyclic Carbenes

Ting Yao, Jiayan Li, Jiaming Wang, Changgui Zhao()   

  1. Key Laboratory of Radiopharmaceuticals, Ministry of Education, College of Chemistry, Beijing Normal University, Beijing 100875
  • Received:2021-09-14 Revised:2021-11-16 Published:2021-12-02
  • Contact: Changgui Zhao
  • Supported by:
    Beijing Natural Science Foundation(2212009); National Natural Science Foundation of China(22171027); Beijing Normal University Startup Funding(312232112)

The seven-membered rings represent an important structural motif and have found wide presence in natural products, biologically active molecules and drugs. In contrast to the five- and six-membered rings, the construction of seven- membered ring remains challenging. Thus, the developing efficient strategies for the synthesis of seven-membered rings is very desirable. N-Heterocyclic carbene (NHC) organocatalysis has been recognized as a powerful and unique tool for the quick construction of complex molecular architectures. Nevertheless, whereas significant advances have been made using NHC as catalysis. However, most of these works concentrated on the assembly of five or six-membered rings. This review highlights the developments and new advances for the construction of seven-membered rings catalyzed by NHC. The aim of this review is to provide an overview of this area and inspire synthetic chemists to develop more efficient and novel strategies for the construction of seven-membered rings.

Key words: N-heterocyclic carbenes, seven-membered ring, asymmetric synthesis, organocatalysis