Chinese Journal of Organic Chemistry ›› 2022, Vol. 42 ›› Issue (5): 1545-1550.DOI: 10.6023/cjoc202111022 Previous Articles     Next Articles



周怡a, 李卓骏a, 胡明辉b, 严兆华a,*(), 林森a,*()   

  1. a 南昌大学化学学院 江西南昌 330031
    b 浙江华海药业股份有限公司 浙江临海 317024
  • 收稿日期:2021-11-13 修回日期:2021-12-31 发布日期:2022-01-20
  • 通讯作者: 严兆华, 林森
  • 基金资助:

Oxidation of Sulfides with SO2F2/H2O2/Base

Yi Zhoua, Zhuojun Lia, Minghui Hub, Zhaohua Yana(), Sen Lina()   

  1. a College of Chemistry, Nanchang University, Nanchang, Jiangxi 330031
    b Zhejiang Huahai Pharmaceutical Co., Ltd., Linhai, Zhejiang 317024
  • Received:2021-11-13 Revised:2021-12-31 Published:2022-01-20
  • Contact: Zhaohua Yan, Sen Lin
  • Supported by:
    National Natural Science Foundation of China(21362022)

A novel oxidation system SO2F2/H2O2/base was investigated for the oxidation of sulfides and the corresponding sulfones were smoothly generated in good to excellent yields. The effects of base and solvent on oxidation were studied. The results showed that this oxidation system is tolerable to a variety of functional groups. A distinct advantage of this method is that by-products resulting from the use of the oxidation system are all water-soluble inorganic compounds, and can be conveniently removed after work-up process, therefore purification of the products is greatly simplified.

Key words: sulfuryl fluoride, hydrogen peroxide, oxidation, sulfides, sulfones