Chin. J. Org. Chem. ›› 2000, Vol. 20 ›› Issue (3): 334-337. Previous Articles     Next Articles

4-取代-脯氨醇催化的前手性酮不对称硼烷还原

张雅文;梁静;陆军;郭聪琳;沈宗旋   

  1. 苏州大学化学化工学院
  • 出版日期:2000-06-25 发布日期:2000-06-25

Asymmetric borane reduction of prochiral ketones catalyzed by 4- substituted prolinol

Zhang Yawen;Liang Jing;Lu Jun;Guo Conglin;Shen Zongxuan   

  • Online:2000-06-25 Published:2000-06-25

(2S)-(diphenylhydroxymethyl)-(4S)-phenoxy-pyrrolidine 10 was prepared from hydroxyproline 6 via a four-step sequence. Using 10 as the catalyst, six prochiral ketones were reduced enantioselectively with borane and the results were compared with those with 1, 1- diphenylprolinol as catalysts.

Key words: HYDROXYPROLINE, BORANE, FIVE MEMBER RING HETEROCYCLIC COMPOUNDS, SELECTIVE REDUCTION, CHIRALITY

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