Chin. J. Org. Chem. ›› 2001, Vol. 21 ›› Issue (3): 223-230. Previous Articles     Next Articles

丹参酮与胺类化合物的反应研究

卜宪章;黄志纾;张敏;马林;肖桂武;钟增培;古练权   

  1. 中山大学化学与化学工程学院;广东省药物研究所.广州
  • 发布日期:2001-03-25

Study on reactions of danshinones with amino compounds

Bu Xianzhang;Huang Zhishu;Zhang Min;Ma Lin;Xiao Guiwu;Zhong Zengpei;Gu Lianquan   

  1. Guangdong Inst of Medica Materials.Guangzhou
  • Published:2001-03-25

Reactions of tanshinones with NH3, CH3NH2, C2H5NH2 and NaOH were investigated. The dihydrofuran ring moiety of tanshinones can be opened by nucleophilic attack in NaOH or NH3 solutions. In CH3NH2 or C2H5NH2 solution, cryptotanshinone form imidazole ring or ozazole ring derivatives of tanshinones respectively. Possible reaction mechanisms were discussed.

Key words: RING CLEAVAGE REACTION, NUCLEOPHILIC REACTION, PROPANAMINE P, REACTION MECHANISM

CLC Number: