Chin. J. Org. Chem. ›› 2001, Vol. 21 ›› Issue (4): 278-284.

### 鬼臼毒素衍生物的量子化学研究

1. 中山医科大学化学教研室;中山医科大学肿瘤研究所.广州(510000);中山大学 化学学院
• 发布日期:2001-04-25

### A quantum chemistry study of podophyllotoxin derivatives

He Feng;Liu Zongchao;Zheng Kangcheng;Yun Fengcun

1. Sun Yat-sen Univ Med Sci., Cancer Res Inst.Guangzhou(510000)
• Published:2001-04-25

A number of podophyllotoxin derivatives were analyzed by AM1 method. Some information from the calculation results and the inhibition of L1210 indicate that there are three structurally distince domains: The C4 position is an effective modified point. The B ring and E ring are important active centers. The results also show that the hole of positive charge in B ring easily combines with an acceptor within the molecule. The E ring along with its C4'xyl group is an important center of negative electricity.

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