Chin. J. Org. Chem. ›› 2005, Vol. 25 ›› Issue (02): 201-203. Previous Articles     Next Articles


6-氟-色满-2-羧酸的合成及其(R)-, (S)-光学异构体的拆分研究


  1. (中国科学院理化技术研究所 北京 100101)
  • 收稿日期:2004-03-13 修回日期:2004-08-30 发布日期:2005-01-15
  • 通讯作者: 王乃兴

Synthesis and Resolution Research of (R)- and (S)-6-Fluorochroman-2-carboxylic Acids

YANG Yun-Xu,WANG Nai-Xing*, SHENG Rui-Long
ZHANG Jun-Ping,YU An-Guang,WANG Wu-Wei   

  1. (Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100101)
  • Received:2004-03-13 Revised:2004-08-30 Published:2005-01-15
  • Contact: WANG Nai-Xing

6-Fluoro-4-chromanone-2-carboxylic acid and 6-fluorochroman-2-carboxylic acid were both synthesized from p-fluorophenol. The (R)- and (S)-6-fluorochroman-2-carboxylic acids were obtained by formation of theirs salts with optical active (R)-(+)- or (S)-(-)-α-methylbenzylamine, respectively.

Key words: synthesis, chemical resolution, 6-fluorochroman-2-carboxylic acid