Chin. J. Org. Chem. ›› 2005, Vol. 25 ›› Issue (02): 204-207. Previous Articles     Next Articles




  1. (中国农业大学应用化学系 北京 100094)
  • 收稿日期:2004-02-10 修回日期:2004-09-01 发布日期:2005-01-15
  • 通讯作者: 杨新玲

Study on the Synthesis and Bioactivity of Pyridazinone Derivatives

LI Hong-Sen,LING Yun,GUO Yu-Lai,YANG Xin-Ling*,CHEN Fu-Heng   

  1. (Department of Applied Chemistry, China Agricultural University, Beijing 100094)
  • Received:2004-02-10 Revised:2004-09-01 Published:2005-01-15
  • Contact: YANG Xin-Ling

Sixteen compounds of pyridazinone derivatives were synthesized. Their structures were determined by 1H NMR, IR spectra and elemental analysis. In the preliminary bioassay test, compounds 7a, 7b, 7c and 7d showed good activity against second-instar housefly larvae and lower activity for third-instar nymphs of locusts at concentration of 200 mg/kg .

Key words: biological activity, synthesis, pyridazinone