Chin. J. Org. Chem. ›› 2005, Vol. 25 ›› Issue (10): 1182-1197. Previous Articles     Next Articles

Review

钯催化反应中的β-氢消除反应

韩秀玲,刘桂霞,陆熙炎*   

  1. (中国科学院上海有机化学研究所金属有机化学国家重点实验室 上海200032)
  • 收稿日期:2004-12-10 修回日期:2005-04-04 出版日期:2005-10-08 发布日期:2005-10-08
  • 通讯作者: 陆熙炎

β-Hydride Elimination in Palladium-Catalyzed Reactions

HAN Xiu-Ling,LIU Gui-Xia,LU Xi-Yan*   

  1. (State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry,
    Chinese Academy of Sciences, Shanghai 200032)
  • Received:2004-12-10 Revised:2005-04-04 Online:2005-10-08 Published:2005-10-08
  • Contact: LU Xi-Yan

Pd(II)-catalyzed reactions were developed using β-heteroatom elimination and protonolysis reaction to quench the carbon-palladium bond in the presence of halide ions or nitrogen ligands (pyridine, bipyridine, phenanthroline, etc.) for the regeneration of the divalent palladium species. Halide ions or nitrogen ligands are necessary for the catalytic cycle and high yield of the reactions. For Pd(0)-catalyzed reactions, control of β-hydride elimination is also a challenge for making coupling reactions more diversified. Different kinds of ligands were used to make the coupling reaction suitable for aliphatic compounds. Recently, examples using chloride ion or bathophenanthroline for this purpose were also developed.

Key words: β-hydride elimination, palladium(II)-catalyzed reaction, cross-coupling reaction, β-heteroatom elimination, protonolysis