Chin. J. Org. Chem. ›› 2006, Vol. 26 ›› Issue (12): 1720-1722. Previous Articles     Next Articles




  1. (a渤海大学应用化学省级重点实验室 锦州 121000)
    (b中国科学院金属研究所金属腐蚀与防护国家重点实验室 沈阳 110016)
  • 收稿日期:2006-06-21 修回日期:2006-09-21 发布日期:2006-11-21
  • 通讯作者: 钱建华

Synthesis of 3,6-Bisubstituted Phenyl-bi-1′,2′,4′-triazolo[3,4-b]-1″,3″,4″-thiadiazole De-rivatives

QIAN Jian-Hua*,a,b,LIU Linb,WANG Dao-Lina,XING Jin-Juana   

  1. (a Provincial Key Laboratory for Applied Chemistry, Bohai University, Jinzhou 121000)
    (b State Key Laboratory for Corrosion and Protection, Institute of Metal Re-search,
    Chinese Academy of Sciences, Shenyang 110016)
  • Received:2006-06-21 Revised:2006-09-21 Published:2006-11-21
  • Contact: QIAN Jian-Hua

2,5-Bihydrazino-1,3,4-thiadiazole was synthesized by substitution of 2,5-bimercapto-1,3,4-thiadiazole with hydrazine hydrate and reacted with benzoyl chloride to give 2,5-biacylhydrazino-1,3,4-thiadiazole, which was further ring-closed by POCl3 as cyclization agent to synthesize 3,6-bisubstituted phenyl-bi-1′,2′,4′-triazolo[3,4-b]-1″,3″,4″-thiadiazole derivatives. The novel compounds were confirmed by elemental analysis, IR, 1H NMR and MS spectra. The mechanism of cycloreaction was also discussed.

Key words: triazolo-1,3,4-thiadiazole, mechanism, 2,5-bihydrazino-1,3,4-thiadiazol, POCl3