Chin. J. Org. Chem. ›› 2006, Vol. 26 ›› Issue (12): 1733-1738. Previous Articles    




  1. (中国药科大学物理化学教研室 南京 210000)
  • 收稿日期:2006-07-28 修回日期:2006-08-24 发布日期:2006-11-21
  • 通讯作者: 黄山

Progress in the New Generation Nonnucleoside Anti-HIV Reverse Transcriptase Inhibitors-TMC125

HOU Jin-Ming,HUANG Shan*   

  1. (Physics Chemistry Office, China Pharmaceutical University, Nanjing 210000)
  • Received:2006-07-28 Revised:2006-08-24 Published:2006-11-21
  • Contact: HUANG Shan

This article summarizes the development and the activity against human immunodeficiency virus type 1 (HIV-1), Nonnucleoside reverse transcriptase inhibitors (NNRTIs)-resistant viruses and HIV-1 group M subtypes of the new generation NNRTIs-TMC125 as well as its metabolic stability assays and the advantage of its combination with other NNRTIs. Besides the same advantage as other NNRTIs, TMC125 was highly active against mutants. It also showed some activity against a series of HIV-1 group M subtypes. Combining TMC125 with other NNRTIs is a potential route against acquired immunodeficiency syndrome (AIDS).

Key words: NNRTIs, HIV, AIDS, TMC125