Chin. J. Org. Chem. ›› 2007, Vol. 27 ›› Issue (11): 1337-1344. Previous Articles     Next Articles




  1. (西北大学生命科学学院 西部资源生物与现代生物技术省部共建教育部重点实验室 西安 710069)
  • 收稿日期:2007-08-18 修回日期:2007-03-09 发布日期:2007-10-20
  • 通讯作者: 王仲孚

Research Progress on Sugar-mimic Derived from Plants

GUO Yu-Na,WANG Zhong-Fu*,HUANG Lin-Juan   

  1. (Key Laboratory of Ministry of Education for Western China Resource Biology and Biotechnology, Life Science College, Northwest University, Xi'an 710069)
  • Received:2007-08-18 Revised:2007-03-09 Published:2007-10-20
  • Contact: WANG Zhong-Fu

Polyhydroxy alkaloids are the compounds in which the oxygen atom of carbohydrate ring is replaced by a nitrogen atom and they are now believed to be widespread in plants and microorganisms. Modern pharmacological studies and clinical practices have confirmed that these compounds can selectively inhibit glycosidases activities. Glycosidases play an important part in many process such as intestinal digestion, post-translation of glycoproteins, the lysosomal catabolism of glycoconjugates, so polyhydroxy alkaloids have intensively therapeutic potential application in diabetes, anticancer, antivirus and the lysosomal diseases treatment. These compounds structures, sources, purification, biological activities, structure-activity relationships and prospects for therapeutic application are summarized.

Key words: sugar-mimic, glycosidase inhibitor, biological activity, polyhydroxy alkaloid