Chin. J. Org. Chem. ›› 2007, Vol. 27 ›› Issue (11): 1409-1413. Previous Articles     Next Articles




  1. (a西北师范大学高分子研究所 兰州 730070)
    (b中国科学院成都分院分析中心 成都 610041)
  • 收稿日期:2006-08-10 修回日期:2007-03-13 发布日期:2007-10-20
  • 通讯作者: 王云普

Synthesis and Crystal Structure of Lappaconitine Hydrobromide

ZHANG Jia,SUN Wen-Xiua,WEN Hui-Huia,LIU Han-Shia
LI Hong-Kuna,YU Kai-Beib,WANG Yun-Pu*,a   

  1. (a Institute of Polymers, Northwest Normal University, Lanzhou 730070)
    (b Analysis and Testing Center Chengdu Branch, Chinese Academy of Sci-ences, Chengdu 610041)
  • Received:2006-08-10 Revised:2007-03-13 Published:2007-10-20
  • Contact: WANG Yun-Pu

A method for the synthesis of lappaconitine hydrobromide by the reaction of dibromoalkyl with lappaconitine is presented. Lappaconitine hydrobromide was determined by IR, 13C NMR, HRMS spectra, elemental analysis and X-ray diffraction analysis. Through intermolecular hydrogen bonding, the similar super molecule netlike structure is formed. Crystal data: monoclinic, P21, a=1.0619(2) nm, b=1.2196(3) nm, c=1.2282(2) nm, β=90.87(1)°, V=1.59037(54) nm3, Z=2, Dm=1.428 g/cm-3, F(000)=720.0, μ=1.349 mm-1. Rings A, B, C, D, E and F present boat, chair, envelope, boat, boat and envelope forms, respectively. The stereo absolute configuration of lappaconitine hydrobromide was determined as 1S,4S,5S,7S,8S, 9S,10S,11S,13R,14S,16S,17R.

Key words: absolute configuration, crystal structure, characterization, synthesis, lappaconitine hydrobromide