Chin. J. Org. Chem. ›› 2007, Vol. 27 ›› Issue (11): 1420-1423. Previous Articles     Next Articles




  1. (a中国矿业大学化工学院 徐州 221116)
    (b徐州师范大学化学系 徐州 221116)
  • 收稿日期:2007-03-07 修回日期:2007-05-24 发布日期:2007-10-20
  • 通讯作者: 梁静

One-Step Syntheses of Pyrano[2,3-d]pyrimidine Derivatives in Aqueous Media Catalyzed by Triethylbenzylammonium Chloride

LIANG Jing*,a,ZHANG Mei-Meib,WEI Xian-Yonga
ZONG Zhi-Mina,WANG Xiang-Shanb   

  1. (a School of Chemical Engineering, China University of Mining and Technology, Xuzhou 221116)
    (b Department of Chemistry, Xuzhou Normal University, Xuzhou 221116)
  • Received:2007-03-07 Revised:2007-05-24 Published:2007-10-20
  • Contact: LIANG Jing

A series of pyrano[2,3-d]pyrimidine derivatives were synthesized from arylidene malononitrile and 1,3-dimethyl barbital at 100 ℃ catalyzed by triethylbenzylammonium chloride (TEBAC) in water. This method has many advantages, such as mild reaction conditions, high yields (78%~90%) and environmental friendliness. The structures of the products were characterized by IR, 1H NMR spectra and elemental analyses, and further confirmed by X-ray diffraction analysis.

Key words: triethylbenzylammonium chloride, water, synthesis, pyrano[2,3-d]pyrimidine