Chin. J. Org. Chem. ›› 2007, Vol. 27 ›› Issue (11): 1428-1431. Previous Articles     Next Articles




  1. (河北大学化学与环境科学学院 河北省分析科学技术重点实验室 保定 071002)
  • 收稿日期:2006-11-27 修回日期:2007-05-08 发布日期:2007-10-20
  • 通讯作者: 李记太

Synthesis of 2,3-Epoxy-1-phenyl-3-(un)substituted Phenyl-1- propanone in Aqueous Media under Ultrasound Irradiation

LI Ji-Tai*,LIU Xian-Feng,LI Xiao-Liang   

  1. (Key Laboratory of Analytical Science and Technology of Hebei Province, College of Chemistry and Environ-mental Science, Hebei University, Baoding 071002)
  • Received:2006-11-27 Revised:2007-05-08 Published:2007-10-20
  • Contact: LI Ji-Tai

Synthesis of 2,3-epoxy-1-phenyl-3-(un)substituted phenyl-1-propanone via Darzens condensation of (un)substituted benzaldehydes with phenacyl chloride was carried out in good yields in the aqueous sodium hydroxide solution under ultrasound irradiation. The combination of phase transfer catalysis and ultrasound irradiation improved the yields. In comparison with the classical methods, this procedure has the advantages of mild conditions, no requirement of toxic solvent, short reaction time and high yields.

Key words: ultrasound irradiation, aqueous media, phase transfer catalysis, Darzens condensation, α,β-epoxy ketone