Chin. J. Org. Chem. ›› 2007, Vol. 27 ›› Issue (11): 1438-1440. Previous Articles     Next Articles



杨勇a,b,叶小利c, 郑静a,d,张保顺a,李学刚*,a   

  1. (a西南大学药学院药用资源化学研究所 重庆 400716)
    (b怀化医学高等专科学校药学系 怀化 418000)
    (c西南大学生命科学学院 重庆 400716)
    (d西南大学化学化工学院 重庆 400716)
  • 收稿日期:2006-12-21 修回日期:2007-02-27 发布日期:2007-10-20
  • 通讯作者: 李学刚

Synthesis of 8-Alkylberberine

YANG Yonga,b,YE Xiao-Lic,ZHENG Jinga,d,ZHANG Bao-Shuna,LI Xue-Gang*,a   

  1. (a Chemistry Institute of Pharmaceutical Resources, School of Pharmaceutical Science, Southwest University,
    Chongqing 400716)
    (b Department of Pharmaceutical Science, Huaihua Medical College, Huaihua 418000)
    (c College of Life Science, Southwest University, Chongqing 400716)
    (d College of Chemistry and Chemical Engi-neering, Southwest University, Chongqing 400716)
  • Received:2006-12-21 Revised:2007-02-27 Published:2007-10-20
  • Contact: LI Xue-Gang

The effects of solvents ether (Et2O), dioxane and tetrahydrofuran on the yield of 8-alkyl substituted berberine derivates with long aliphatic chains were studied. Results showed that when tetrahydrofuran was used as a solvent, the yields of 8-decyl-, and 8-dodecyl-berberines were 4 times higher than those in ether.

Key words: synthesis, solvent effect, 8-alkyl substituted berberine derivate