In order to find novel low toxicity and potent herbicides, ten title compounds were synthesized by the multi-step reaction using 2-chloro-5-(chloromethyl)pyridine or 2-chloro-5-(chloromethyl)thiazole as starting materials. The structures of the target compounds were characterized by IR, ¹H NMR, MS spectra and elemental analysis. Preliminary bioassays show that some of the target compounds possess good herbicidal activities against selected weeds at a concerntration of 100 mg/L.