Chin. J. Org. Chem. ›› 2008, Vol. 28 ›› Issue (08): 1462-1466. Previous Articles     Next Articles



陆鸿飞*,a ; 韩光范a ; 陆 明b   

  1. (a江苏科技大学材料科学与工程学院 镇江 212003)
    (b南京理工大学化工学院 南京 210094)
  • 收稿日期:2007-05-17 修回日期:2008-02-11 发布日期:2008-08-18
  • 通讯作者: 陆鸿飞

Synthesis of 6-Fluorine-substituted-purine Derivatives

LU, Hong-Fei*,a; HAN, Guang-Fana ; LU, Mingb   

  1. (a School of Material Science and Engineering, Jiangsu University of Science and Technology, Zhenjiang 212003)
    (b Chemical Engineering School, Nanjing University of Science and Technology, Nanjing 210094)
  • Received:2007-05-17 Revised:2008-02-11 Published:2008-08-18
  • Contact: LU, Hong-Fei

Using 6-chloropurine as a starting material, 6-fluoropurine derivatives were prepared through the reaction of halogen exchange. 6-Trifluoethoxylpurine derivatives were prepared through substitution by β,β,β-trifluoroethoxyl sodium, while 6-trifluomethylpurine derivatives were prepared by the trifluomethyl action with CF3COONa/CuI/DMF at 160 ℃. All of the products were characterized by 1H NMR, mass spectra and elemental analysis. Fungicidal activities of all compounds were tested, showing that compounds 2b and 4b have good activity to Bacillus subtillis, compounds 4a and 4b have good activity to Aspergillus niger, and compounds 3b and 4b have good activity to Cardida tropicals.

Key words: purine, trifluoroethoxyl, trifluoromethyl, preparation, fluorine