Chin. J. Org. Chem. ›› 2008, Vol. 28 ›› Issue (09): 1545-1552.
HAO, Ge-Fei; YANG, Guang-Fu*
his article summarizes the discovery, activity, molecular mechanism and structural optimization of nonpeptide sulfonamide anti-HIV (human immunodeficienty virus) protease inhibitor darunavir (TMC-114), which has not only a good inhibitory effect on wildtype HIV protease, but also fantastic inhibitory effects on many mutated HIV proteases, and is a new drug developed for HIV’s resistance.
acquired immure deficiency syndrome (AIDS),
HIV protease inhibitor
HAO, Ge-Fei; YANG, Guang-Fu*. Progress in the New Generation Nonpeptide Sulfonamide Anti-HIV Protease Inhibitor Darunavir[J]. Chin. J. Org. Chem., 2008, 28(09): 1545-1552.
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