Chin. J. Org. Chem. ›› 2008, Vol. 28 ›› Issue (09): 1545-1552. Previous Articles     Next Articles

Review

新型非拟肽磺胺类HIV蛋白酶抑制剂Darunavir的研究进展

郝格非; 杨光富*   

  1. 华中师范大学化学学院 农药与化学生物学教育部重点实验室 武汉 430079
  • 收稿日期:2007-09-11 修回日期:2007-12-03 发布日期:2008-09-20
  • 通讯作者: 杨光富

Progress in the New Generation Nonpeptide Sulfonamide Anti-HIV Protease Inhibitor Darunavir

HAO, Ge-Fei; YANG, Guang-Fu*   

  1. Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, College of Chemistry,
    Central China Normal University, Wuhan 430079
  • Received:2007-09-11 Revised:2007-12-03 Published:2008-09-20
  • Contact: YANG, Guang-Fu

his article summarizes the discovery, activity, molecular mechanism and structural optimization of nonpeptide sulfonamide anti-HIV (human immunodeficienty virus) protease inhibitor darunavir (TMC-114), which has not only a good inhibitory effect on wildtype HIV protease, but also fantastic inhibitory effects on many mutated HIV proteases, and is a new drug developed for HIV’s resistance.

Key words: darunavir (TMC-114), acquired immure deficiency syndrome (AIDS), resistant mutati, HIV protease inhibitor