Chin. J. Org. Chem. ›› 2008, Vol. 28 ›› Issue (09): 1553-1560. Previous Articles     Next Articles



姚元山a,b ; 姚祝军*,a   

  1. (a中国科学院上海有机化学研究所生命有机化学国家重点实验室 上海 200032)
    (b中国科技大学化学系 合肥 230026)
  • 收稿日期:2007-11-02 修回日期:2008-02-18 发布日期:2008-09-20
  • 通讯作者: 姚祝军

Total Synthesis of Platensimycin: a Review

YAO, Yuan-Shana,b ; YAO, Zhu-Jun*,a   

  1. (a State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry,
    Chinese Academy of Sciences, Shanghai 200032)
    (b Department of Chemistry, University of Science and Technology of China, Hefei 230026)
  • Received:2007-11-02 Revised:2008-02-18 Published:2008-09-20
  • Contact: YAO, Zhu-Jun

Platensimycin represents a unique structural class of antibiotics acting with a novel and highly selective mechanism. Its potent antibacterial activity and interesting chemical structure have attracked great attention of scientific community, and have made it an attractive target for chemical synthesis. This review summarizes the total syntheses of platensimycin and its analogues since its discovery in 2006.

Key words: platensimycin, natural product, total synthesis, cage-like tetracyclic core, antibiotic