Chin. J. Org. Chem. ›› 2008, Vol. 28 ›› Issue (09): 1566-1571. Previous Articles     Next Articles

Original Articles

2-溴-4-[1-(E)-亚乙基-2-对甲氧基苯基-丁基]-1-甲氧基苯脱甲基及双键转位反应的研究

金蔚蔚; 吴文彦; 张 倩*; 夏 鹏   

  1. 复旦大学药学院 上海 200032
  • 收稿日期:2008-01-07 修回日期:1900-01-01 发布日期:2008-09-20
  • 通讯作者: 张 倩

Demethylation and Double-Bond Isomerisation of 2-Bromo-4-[1-eth- (E)-ylidene-2-(4-methoxy-phenyl)-butyl]-1-methoxy-benzene

JIN, Wei-Wei ; WU, Wen-Yan ; ZHANG, Qian* ; XIA, Peng   

  1. (School of Pharmacy, Fudan University, Shanghai 200032)
  • Received:2008-01-07 Revised:1900-01-01 Published:2008-09-20
  • Contact: ZHANG, Qian

Some different demethylation products and the double bond isomer of 2-bromo-4-[1-eth-(E)- ylidene-2-(4-methoxy-phenyl)-butyl]-1-methoxy-benzene (3) were obtained under different conditions dur-ing synthesizing 3’-methoxyl-1,2-diethystilbestrol (2). The angiogenesis inhibitory activities of some com-pounds were evaluated on human umbilical vein endothelial cells and the assay data indicated that the groups substituted on the skeleton of diethystilbestrol analogs could significantly affect their anti-angiogenesis activities.

Key words: 2-bromo-4-[1-eth-(E)-ylidene-2-(4-methoxy-phenyl)-butyl]-1-methoxy-benzene, isomerisation of double bond reaction, angiogenesis inhibitor, demethylation reaction