Chin. J. Org. Chem. ›› 2008, Vol. 28 ›› Issue (09): 1578-1583.
李家明*,a ; 赵永海a ; 马逢时a ; 汪志勇b ;何 勇a ; 张德帅a ; 任海波a
LI, Jia-Ming*,a ; ZHAO, Yong-Haia; MA, Feng-Shia; WANG, Zhi-Yongb HE, Yonga ; ZHANG, De-Shuaia; REN, Hai-Boa
Ligustrazine and ferulic acid, which are useful compounds of Chinese traditional medicine, were used as leading compounds. Six ligustrazine-aromatic acid derivatives were designed and synthesized based on the twin drug principle. Their structures were characterized by IR, 1H NMR, 13C NMR and mass spectra. In the in vivo experiment, some compounds have significant inhibitory effect on adenosine diphosphate (ADP) induced platelet aggregation. Among them, the inhibitory effect of compound 1a was 5.7 times than ozagrel.
ligustrazine-aromatic acid derivative,
platelet aggregation inhibitory,
LI, Jia-Ming*,a ; ZHAO, Yong-Haia; MA, Feng-Shia; WANG, Zhi-Yongb HE, Yonga ; ZHANG, De-Shuaia; REN, Hai-Boa . Synthesis of Ligustrazine-Aromatic Acid Derivatives and Their Inhibitory Effect on Platelet Aggregation[J]. Chin. J. Org. Chem., 2008, 28(09): 1578-1583.
Export EndNote|Reference Manager|ProCite|BibTeX|RefWorks