Chin. J. Org. Chem. ›› 2008, Vol. 28 ›› Issue (09): 1616-1619. Previous Articles     Next Articles



孙 晶 ; 张丽丽 ; 柳冬梅; 高 卉; 颜朝国*   

  1. (扬州大学化学化工学院 扬州 225002)
  • 收稿日期:2008-01-22 修回日期:2008-03-07 发布日期:2008-09-20
  • 通讯作者: 颜朝国

One-Pot Synthesis of 2-Amino-3-cyano-4-[(un)substituted phenyl]-6-ferrocenylpyridines

SUN, Jing; ZHANG, Li-Li;LIU, Dong-Mei;GAO, Hui;YAN, Chao-Guo*   

  1. (College of Chemistry & Chemical Engineering, Yangzhou University, Yangzhou 225002)
  • Received:2008-01-22 Revised:2008-03-07 Published:2008-09-20
  • Contact: YAN, Chao-Guo

One-pot multicomponent reactions of acetylferrocene, (un)substituted benzaldehyde and malononitrile in refluxing ethanol with ammonium acetate as a catalyst gave 2-amino-3-cyano-4- [(un)substituted phenyl]-6-ferrocenylpyridines in moderate yields. Eight ferrocenyl pyridine derivatives were prepared efficiently and one single crystal structure of 4e was determined.

Key words: multicomponent reaction, ferrocene, pyridine, malononitrile, benzaldehyde, one-pot reaction