Chin. J. Org. Chem. ›› 2008, Vol. 28 ›› Issue (10): 1724-1728. Previous Articles     Next Articles

Original Articles


陈 丽a ; 马梦林b; 彭宗海a; 陈 华*,a   

  1. (a四川大学化学学院有机金属络合催化研究所 绿色化学与技术教育部重点实验室 成都 610064)
    (b西华大学化学系 成都 611930)
  • 收稿日期:2007-07-13 修回日期:2008-03-20 发布日期:2008-10-20
  • 通讯作者: 陈 华

Synthesis of a New Bipyridyl Diphosphine Ligand and Its Application to Asymmetric Hydrogenation of β-Keto Esters

CHEN, Lia ; MA, Meng-Linb ; PENG, Zong-Haia ; CHEN, Hua*,a   

  1. (a Key Laboratory of Green Chemistry & Technology, Ministry of Education, Institute of Homogeneous Catalysis,
    Faculty of Chemistry, Sichuan University, Chengdu 610064)
    (b Department of Chemistry, Xihua University Chengdu 611930)
  • Received:2007-07-13 Revised:2008-03-20 Published:2008-10-20
  • Contact: CHEN, Hua

A new electron-donating diphosphine (R)-MeO-P-Phos [(R)-2,2’,6,6’-tetramethoxy-4,4’- bis[di(4-meth- oxylphenyl)phosphino]-3,3’-bipyridine] has been synthesized and its application to the asymmetric hydrogenation of β-keto esters catalyzed by ruthenium complex was explored. Solvent effect was tested and up to 99.1% ee was achieved for the hydrogenation of ethyl acetoacetate in EtOH. The asymmetric hydrogenation of various β-keto esters catalyzed by Ru-MeO-P-Phos was investigated.

Key words: β-keto ester, asymmetric hydrogenation, chiral diphosphine, enantioselectivity