Chin. J. Org. Chem. ›› 2009, Vol. 29 ›› Issue (04): 658-662. Previous Articles     Next Articles

Reports

细胞色素p450的结构与催化机理

王 斌*; 李德远

  

  1. (军事经济学院军需系营养与食品研究所 武汉 430035)
  • 收稿日期:2008-06-21 修回日期:2008-09-12 出版日期:2009-04-20 发布日期:2009-04-20
  • 通讯作者: 王 斌

Structure and Catalytic Mechanism of Cytochrome P450

Wang, Bin* ; Li, Deyuan   

  1. (Institute of Nutrition Food, Military Economy Academy, Wuhan 430035)
  • Received:2008-06-21 Revised:2008-09-12 Online:2009-04-20 Published:2009-04-20
  • Contact: Wang, Bin

P450 enzymes are ubiquitous heme-containing monooxygenases and involved in a number of vital processes including carcinogenesis and drug metabolism as well as the biosynthesis of steroid hormones and fat-soluble vitamin metabolism and the conversion of polyunsaturated fatty acids to biologically active molecules. Recent advances in understanding structure-function relationships in cytochrome P450 are summarized. Of particular importance is the role that plays in P450 function, where the active site undergoes large open/close motions to enable substrates to bind and products to leave and electron transfer pathways.

Key words: cytochrome P450, hydroxylation, structure, catalytic mechanism, function