Chin. J. Org. Chem. ›› 2009, Vol. 29 ›› Issue (07): 1068-1081. Previous Articles     Next Articles



李运波 ; 唐凤翔*; 孟 春; 郭养浩   

  1. (福州大学药物生物技术与工程研究所 福州 350108)
  • 收稿日期:2008-06-21 修回日期:2008-10-25 出版日期:2009-07-22 发布日期:2009-07-22
  • 通讯作者: 唐凤翔

Progress in the Synthesis and Application of Nipecotic Acid and Its Derivatives

Li, Yunbo ; Tang, Fengxiang*; Meng, Chun; Guo, Yanghao   

  1. (Institute of Pharmaceutical Biotechnology and Engineering, Fuzhou University, Fuzhou 350108)
  • Received:2008-06-21 Revised:2008-10-25 Online:2009-07-22 Published:2009-07-22
  • Contact: Tang, Fengxiang

Nipecotic acid and its derivatives, which have high bioactivity, are significant pharmaceutical intermediates. In this review, the synthetic methods of nipecotic acid and its derivatives are summarized. The application of nipecotic acid and its derivatives to synthesizing drugs for γ-aminobutyric acid (GABA) uptake inhibition, cancer chemotherapy, growth hormone secretion, anti-inflammation, cardiovascular disease Alzheimer’s disease, nootropics, anti-flu virus and bone disease is presented as well.

Key words: nipecotic acid derivative, pharmaceutical intermediate, nipecotic acid