Chin. J. Org. Chem. ›› 2009, Vol. 29 ›› Issue (07): 1096-1099. Previous Articles     Next Articles

Original Articles

异维A酸二茂铁基衍生物的合成及其细胞毒活性的研究

梁盛宗a ; 忻鼎丞a ; 龙伯华a; 向建南*,a,b,c   

  1. (a湖南大学化学化工学院 长沙 410082)
    (b湖南大学生物医学工程中心 长沙 410082)
    (c湖南大学化学生物传感与计量学国家重点实验室 长沙 410082)
  • 收稿日期:2008-11-17 修回日期:2008-12-17 出版日期:2009-07-22 发布日期:2009-07-22
  • 通讯作者: 向建南

Synthesis and Cytotoxic Activities of 13-cis-Retinoyl Ferrocene Derivatives

Liang, Shengzonga ; Xin, Dingchena; Long, Bohuaa ; Xiang, Jiannan*,a,b,c   

  1. (a College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082)
    (b Bio-medicine Engineering Center, Hunan University, Changsha 410082)
    (c State Key Laboratory of Chem/Biosensing and Chemometrics, Hunan University, Changsha 410082)
  • Received:2008-11-17 Revised:2008-12-17 Online:2009-07-22 Published:2009-07-22
  • Contact: Xiang, Jiannan

In order to decrease toxicities of retinoids, enhance their physiological activities against cancer cells and increase absorbency in the organisms, eight novel 13-cis-retinoyl ferrocene derivatives were synthesized in yields higher than 80% through Mitsunobu reactions. Their structures were characterized and their cytotoxic activities were determined in vitro by an 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay using human cancer lines including A549 cells lines etc. Results showed that the 13-cis-retinoyl ferrocene derivatives modified by ferrocene groups exhibited excellent cytotoxic activities against cancer cells.

Key words: cytotoxic activity, ferrocene derivative, Mitsunobu reaction, 13-cis-retinoic acid