Chin. J. Org. Chem. ›› 2009, Vol. 29 ›› Issue (07): 1100-1104. Previous Articles     Next Articles

Original Articles

新型N-(5-烷基-1,3,4-噻二唑-2-基)-1-[(杂芳基)甲基]-5-甲基-1H-1,2,3-三唑基-4-甲酰胺的合成与生物活性

陈小保a,b; 石德清*,a   

  1. (a华中师范大学化学学院 农药与化学生物学教育部重点实验室 武汉 430079)
    (b郧阳医学院药物化学系 十堰 442000)
  • 收稿日期:2008-12-02 修回日期:2008-12-22 出版日期:2009-07-22 发布日期:2009-07-22
  • 通讯作者: 石德清

Synthesis and Biological Activities of Novel N-(5-Alkyl-1,3,4- thiadiazol-2-yl)-1-[(heteroaryl)methyl]-5-methyl-1H-1,2,3- triazole-4-carboxamides

Chen, Xiaobao a,b; Shi, Deqing*,a   

  1. (a Key Laboratory of Pesticide and Chemical Biology of Ministry of Education, College of Chemistry,
    Central China Normal University, Wuhan 430079)
    (b Department of Medicinal Chemistry, Yunyang Medical College, Shiyan 442000)

  • Received:2008-12-02 Revised:2008-12-22 Online:2009-07-22 Published:2009-07-22
  • Contact: Shi, Deqing

In search of novel low toxicity and potent pesticide lead compounds, eight title compounds were synthesized via the condensation reactions of 1-[(heteroaryl)methyl]-5-methyl-1H-1,2,3-triazole-4-carbonyl chlorides with 5-alkyl-2-amino-1,3,4-thiadiazoles, and structurally characterized by IR, 1H NMR spectra, and elemental analysis or further by MS technique. Preliminary bioassays showed that a fraction of the target compounds possessed moderate herbicidal activities against dicotyledonous plants (Brassica campestris L) at the concerntration of 100 mg/L and insecticidal activity to some extent at the concerntration of 250 mg/L.

Key words: 1,3,4-thiadiazole, thiazole, biological activity, 1,2,3-triazole, substituted pyridine