Chin. J. Org. Chem. ›› 2009, Vol. 29 ›› Issue (09): 1317-1324. Previous Articles     Next Articles

Review

唾液酸糖苷化反应研究新进展

梁芬芬 陈 力 邢国文*   

  1. (北京师范大学化学学院 北京 100875)
  • 收稿日期:2008-09-02 修回日期:2008-12-26 出版日期:2009-09-28 发布日期:2009-12-30
  • 通讯作者: 邢国文

Recent Advances in Sialylation

Liang, Fenfen Chen, Li Xing, Guowen*   

  1. (College of Chemistry, Beijing Normal University, Beijing 100875)
  • Received:2008-09-02 Revised:2008-12-26 Online:2009-09-28 Published:2009-12-30
  • Contact: Xing, Guowen

Sialic acid is a kind of important sugar acid compound, which has many biological functions. The reaction conditions of sialylation reactions are harsher than the common glycosylation reactions, the stereoselectivities are usually poor, and the configuration of anomeric carbon is difficult to control. Whether α glycosidic bond can be constructed efficiently in sialylation reactions is one of the important criteria to evaluate the reaction quality. Study of sialylation methods generally relates to following areas: the use of different leaving groups at C-2, participation of auxiliary groups at C-1 and C-3, the modification of protec-tive group of NHAc at C-5 and the development of some new promoters. In recent years, these research ar-eas, especially the study of protective group of NHAc at C-5, have made important progress. Herein, we pre-dominately make a summary and review on the new progress of sialylation methods.

Key words: glycosylation, oxazolidone, sialic acid