Synthesis of Chromeno[3,4-c]pyridin-5-ones
LI Gu-Cai*,YIN Duan-Zhi,SHEN Yu-Mei,WANG Yong-Xian
(Research Center of Radiopharmaceuticals, Shanghai Institute of Applied Physics,
Chinese Academy of Sciences, Shanghai 201800)
A series of novel chromeno[3,4-c]pyridin-5-ones as potential dopamine D4 receptor ligands were prepared from proper phenols and methyl-4-oxo-3-piperidine carboxylate hydrochloride through intermolecular cycloaddition and N-alkylation reaction. Their structures were confirmed by elemental analysis, IR, 1H NMR and ESI-MS spectra.