Chin. J. Org. Chem. ›› 2006, Vol. 26 ›› Issue (03): 292-298. Previous Articles     Next Articles

Review

β-内酰胺类抗生素酶促合成新进展

吴伟波1,王旭2,王娜1,吴起1,林贤福*,1   

  1. (1浙江大学化学系 杭州 310027)
    (2浙江工业大学化工与材料学院 杭州 310032)
  • 收稿日期:2005-01-27 修回日期:2005-08-11 出版日期:2006-02-28 发布日期:2006-02-28
  • 通讯作者: 林贤福

New Progress in Enzymatic Semi-Synthesis of β-Lactam Antibiotics

WU Wei-Bo1,WANG Xu2,WANG Na1,WU Qi1,LIN Xian-Fu*,1   

  1. (1 Department of Chemistry, Zhejiang University, Hangzhou 310027)
    (2 Institute of Chemical Engineering and Material Science, Zhejiang University of Technol-ogy, Hangzhou 310032)
  • Received:2005-01-27 Revised:2005-08-11 Online:2006-02-28 Published:2006-02-28
  • Contact: LIN Xian-Fu

Semi-synthetic β-lactam antibiotics plays a significant role in pharmaceutical industry. Enzymatic synthesis of β-lactam antibiotics provides an effective green technology, which could decline the generation of waste and the cost of production remarkably. This review focuses on the recent progresses of enzymatic semi-synthesis of β-lactam antibiotics, mainly including one-pot synthesis, in situ product removal, media techniques and immobilization techniques of enzyme.

Key words: penicillin, green technology, cephalosporin, enzymatic synthesis, β-lactam antibiotics