Chin. J. Org. Chem. ›› 2008, Vol. 28 ›› Issue (08): 1379-1384. Previous Articles     Next Articles

Original Articles


安林坤* ; 邹 兰; 王晓冬 ; 武 宁; 沈德清; 卜宪章; 黄志纾; 古练权

  1. (中山大学药学院 广州 510275)
  • 收稿日期:2007-09-09 修回日期:2008-01-09 发布日期:2008-08-18
  • 通讯作者: 安林坤

Synthesis of 1-[2-(Hydroxymethyl)-1,3-oxathiolanyl]pyridinone Analogues

AN, Lin-Kun* ; ZOU, Lan ; WANG, Xiao-Dong; WU, Ning; SHEN, De-Qing; BU, Xian-Zhang; HUANG, Zhi-Shu; GU, Lian-Quan

  1. (School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510275)
  • Received:2007-09-09 Revised:2008-01-09 Published:2008-08-18
  • Contact: AN, Lin-Kun

The synthesis of 1,3-oxathiolane nucleoside derivatives was investigated. A series of novel 1,3-oxathiolane nucleoside derivatives, in which the bases have been replaced by pyridinone derivatives, were synthesized by the Vorbruggen coupling method using TMSOTf as the catalyst, and then deprotection or reduction reactions. Their antimicrobial activity was determined, showing that they had moderate activity against G+ microbial.

Key words: pyridinone, Vorbruggen coupling method, nucleoside derivative