Chin. J. Org. Chem. ›› 2008, Vol. 28 ›› Issue (10): 1820-1825. Previous Articles     Next Articles


[5-(芳亚甲基氨基)-1,3,4-噻二唑-2-基]硫乙酰芳胺的合成及 生物活性研究

魏太保a ; 王文利a ; 郭潇迪a ; 徐 蓉a; 张有明*,a ; 达文燕b   

  1. (a西北师范大学化学化工学院 甘肃省高分子材料重点实验室 兰州 730070)
    (b西北师范大学生命科学学院 兰州 730070)
  • 收稿日期:2008-03-07 修回日期:2008-04-04 发布日期:2008-10-20
  • 通讯作者: 张有明

Synthesis and Biological Activity of [5-(Arylmethylideneamino)- 1,3,4-thiadiazol-2-yl]thioacetanilides

WEI, Tai-Baoa ; WANG, Wen-Lia ; GUO, Xiao-Dia ; XU, Ronga;
ZHANG, You-Ming*,a; DA, Wen-Yanb

  1. (a Gansu Key Laboratory of Polymer Materials, College of Chemistry and Chemical Engineering,
    Northwest Normal University, Lanzhou 730070)
    (b College of Life Science, Northwest Normal University, Lanzhou 730070)
  • Received:2008-03-07 Revised:2008-04-04 Published:2008-10-20
  • Contact: ZHANG, You-Ming

Sixteen novel derivatives of [5-(arylmethylideneamino)-1,3,4-thiadiazol-2-yl]thioacetanilide were synthesized by the reaction of S-alkylation of 5-arylmethylideneamino-2-mercapto-1,3,4-thiadiazole with chloroacetanilides under the conditions of solid-liquid phase transfer catalysis using PEG-400 as a phase transfer catalyst in the presence of potassium carbonate. All the products were characterized by elemental analysis, FT-IR, 1H NMR and 13C NMR spectra. The preliminary biological activity tests showed that some of the title compounds had obvious regulating activities for the growth of wheat, and some compounds such as 4a and 4e possessed satisfactory activity of growth inhibition against B. subtilis at a test concentration (20 mg/mL).

Key words: synthesis, [5-(arylmethylideneamino)-1,3,4-thiadiazol-2-yl]thioacetanilide, bioactivity, phase transfer catalysis