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   Chin. J. Org. Chem.  2010, Vol. 30  Issue (03) :452-455    DOI:
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   Microwave-Assisted Synthesis of 2-Substituted-4(3H)-quinazolinones in Br?nsted Acidic Ionic Liquids
   Li Xinzhong*,a,Lin Qia,Wumanjiang Elib
   (a Department of Chemistry and Chemical Engineering, Minjiang University, Fuzhou 350108)
(b Xinjiang Technical Institute of Physics & Chemistry, Chinese Academy of Sciences, Urumqi 830011)
 
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LI Xin-Zhong
LIN Ji
WU Man-Jiang-?Ai-Li
Abstract: Two novel Br?nsted acidic ionic liquids 1-(4-sulfonic)-benzyl-3-methylimidazolium hydrogen sulfate (3a) and N-(4-sulfonic)-benzyl-pyridium hydrogen sulfate (3b) were synthesized using N-methyli- midazole and pyridine as starting materials, which acted as catalyst and reaction medium for the synthesis of 2-substituted-4(3H)-quinazolinones under three-component, one-pot, and microwave irradiation conditions. Under the optimized conditions of n(2-amino-benzoic acid)∶n(acylchloride)∶n(ammonium acetate)∶n(3a or 3b)=1∶1.2∶1.5∶0.1, the reactions completed within 6 min with the yields of 81%~95%. 3a or 3b could be recycled three times without any significant loss in catalytic activity after reduced pressure distillation and drying under vacuum .
KeywordsBr?nsted acid,   ionic liquid,   multi-component reaction,   microwave,   4(3H)-quinazolinone     
Received: 2009-06-24; published: 2010-03-28
Cite this article:   
LI Xin-Zhong, LIN Ji, WU Man-Jiang-?Ai-Li .Microwave-Assisted Synthesis of 2-Substituted-4(3H)-quinazolinones in Br?nsted Acidic Ionic Liquids[J]  Chin. J. Org. Chem. 2010,V30(03): 452-455
URL:  
http://sioc-journal.cn/Jwk_yjhx/EN/     或     http://sioc-journal.cn/Jwk_yjhx/EN/Y2010/V30/I03/452
 
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