Chin. J. Org. Chem. ›› 2010, Vol. 30 ›› Issue (05): 648-654. Previous Articles     Next Articles




  1. (1华南师范大学化学与环境学院 广州 510006)
    (2广东高校新材料工程技术开发中心 湛江 524048)
    (3湛江师范学院化学系 湛江 524048)
  • 收稿日期:2009-07-27 修回日期:2009-09-03 出版日期:2010-05-25 发布日期:2009-11-03
  • 通讯作者: 汪朝阳
  • 基金资助:


Progress in Reactions of 2(5H)-Furanone with Nucleophiles Containing Nitrogen

Song Xiumei1,2,3 Li Jianxiao1 Wang Zhaoyang*,1 Mo Yangqing1   

  1. (1 Department of Chemistry, South China Normal University, Guangzhou 510006)
    (1 Development Center for New Materials Engineering & Technology in Universities of Guangdong, Zhanjiang 524048)
    (3 Department of Chemistry, Zhanjiang Normal College, Zhanjiang 524048)
  • Received:2009-07-27 Revised:2009-09-03 Online:2010-05-25 Published:2009-11-03
  • Contact: Zhaoyang Wang

As a kind of α,β-unsaturated butyrolactone, 2(5H)-furanone is so reactive in lots of reactions that it has been used extensively in organic synthesis, especially, when a halogen atom is attached to the C=C unsaturated bond. According to the different reaction points, the recent advance in reactions of 2(5H)-furanone with nucleophiles containing nitrogen to give cyclic derivatives with β-substituent, α,β-disubstituents or γ-substituent via Michael addition, tandem Michael addition-elimination, dipolar cycloaddition or palladium-catalyzed cross-coupling reactions is reviewed.

Key words: 2(5H)-furanone, nucleophile containing nitrogen, Michael addition, dipolar cycloaddition, tandem reaction