Chin. J. Org. Chem. ›› 2011, Vol. 31 ›› Issue (10): 1582-1594. Previous Articles     Next Articles

Reviews

普瑞巴林的合成研究进展

陈永升,李勋,程若男,赵圣印*   

  1. (东华大学化学化工与生物工程学院 上海 201620)
  • 收稿日期:2010-09-09 修回日期:2011-03-21 出版日期:2011-10-25 发布日期:2011-03-24
  • 通讯作者: 赵圣印 E-mail:syzhao8@dhu.edu.cn

Recent Development in the Synthesis of Pregabalin

CHEN Yong-Sheng, LI Xun, CHENG Ruo-Nan, ZHAO Sheng-Yin   

  1. (College of Chemistry, Chemical Engineering & Biotechnology, Donghua University, Shanghai 201620)
  • Received:2010-09-09 Revised:2011-03-21 Online:2011-10-25 Published:2011-03-24

Pregabalin, a lipophlic γ-aminobutyric acid (GABA) analogue, was developed for the treatment of several central nervous system disorders including epilepsy, neuropathic pain, anxiety and social phobia. The main new synthetic methods of pregabalin are summarized according to asymmetric synthetic methodology, especially on kinetic resolution, desymmetrization reaction, asymmetric hydrogenation, asymmetric Michael addition and so on.

Key words: pregabalin, kinetic resolution, asymmetric synthesis