Chin. J. Org. Chem. ›› 2012, Vol. 32 ›› Issue (01): 133-137.DOI: 10.6023/cjoc1104011 Previous Articles     Next Articles



李财虎a, 杨聪玲b, 张宽a, 石万棋c, 李剑忠b, 李颖a, 尹述凡a   

  1. a 四川大学化学学院 成都 610064;
    b 四川师范大学化学与材料科学学院 成都 610066;
    c 四川国康药业有限公司 成都 610041
  • 收稿日期:2011-04-01 修回日期:2011-08-03 发布日期:2011-09-09
  • 通讯作者: 尹述凡;;

Synthesis and Anti-inflammatory Activity of Novel Benzimidazole (Benzothiazole) Phenylursolate

Li Caihua, Yang Conglingb, Zhang Kuana, Shi Wanqic, Li Jianzhongb, Li Yinga, Yin Shufana   

  1. a Faculty of Chemistry Sichuan University, Chengdu 610064;
    b College of Chemical and Material Science, Sichuan Normal University, Chengdu 610066;
    c Sichuan Guokang Pharmaceutical Co., Ltd, Chengdu 610041
  • Received:2011-04-01 Revised:2011-08-03 Published:2011-09-09
  • Contact: Yin Shufan;;

A novel series of the benzimidazole or benzothiazole phenyl ester derivatives of ursolic acid 4a4h were prepared via ursolic acid, substituted benzaldehyde, and o-phenylendiamine or 2-aminothiophenol. The compounds were structurally confirmed by 1H NMR, IR and HRMS techniques. The preliminary bioassay test demonstrated that compounds 4d and 4g had potent anti-inflammatory activity.

Key words: ursolic acid, benzimidazole, benzothiazole, anti-inflammatory