Chin. J. Org. Chem. ›› 2012, Vol. 32 ›› Issue (11): 2129-2133.DOI: 10.6023/cjoc201205016 Previous Articles     Next Articles



纪增臣a, 刘峰a, 张泽远b, 李付博a, 姜林b   

  1. a 山东农业大学植物保护学院 泰安 271018;
    b 山东农业大学化学与材料科学学院 泰安 271018
  • 收稿日期:2012-05-12 修回日期:2012-07-05 发布日期:2012-07-09
  • 通讯作者: 姜林
  • 基金资助:

    山东省自然科学基金(No. ZR2009BM044)资助项目.

Synthesis and Antifungal Activity of Novel 2-(1H-Benzimidazol-2-yl)-5-substituted-1,3,4-oxadiazole Derivatives

Ji Zengchena, Liu Fenga, Zhang Zeyuanb, Li Fuboa, Jiang Linb   

  1. a College of Plant Protection, Shandong Agricultural University, Taian 271018;
    b College of Chemistry and Material Science, Shandong Agricultural University, Taian 271018
  • Received:2012-05-12 Revised:2012-07-05 Published:2012-07-09
  • Supported by:

    Project supported by the Natural Science Foundation of Shandong Province (No. ZR2009BM044).

Sixteen novel 2-(1H-benzimidazol-2-yl)-5-substituted phenyl-1,3,4-oxadiazoles and 2-(1H-benzimidazol-2-yl)-5-substituted phenylamino-1,3,4-oxadiazoles were synthesized from benzimidazole-2-carboxylic acid, hydrazine hydrate, substituted phenyl isothiocyanate and substituted benzoic acid by multi-step reactions. The target compounds were evaluated for their antifungal activities against Botrytis cinerea and Sclerotinia sclerotiorum, and the results indicated that three target compounds displayed excellent antifungal activities against Botrytis cinerea, with EC50 values of 2.55, 6.34 and 5.12 μg/mL, respectively, even higher than that of carbendazim.

Key words: benzimidazole, 1,3,4-oxadiazole, synthesis, antifungal activity