Chin. J. Org. Chem. ›› 2013, Vol. 33 ›› Issue (02): 348-352.DOI: 10.6023/cjoc201209025 Previous Articles     Next Articles



方正东, 方迪, 陈全   

  1. 湖北师范学院化学与环境工程学院 黄石 435002
  • 收稿日期:2012-09-18 修回日期:2012-10-13 发布日期:2012-10-25
  • 通讯作者: 方正东
  • 基金资助:

    湖北省自然科学基金(No. 2010CDA061)资助项目.

Three-Component Synthesis of 1,4-[6,6'-(3-Trifluoromethyl-pyrazolo[3,4-d]pyrimidinyl)]piperazines

Fang Zhengdong, Fang Di, Chen Quan   

  1. College of Chemistry and Environmental Engineering, Hubei Normal University, Huangshi 435002
  • Received:2012-09-18 Revised:2012-10-13 Published:2012-10-25
  • Supported by:

    Project supported by the Natural Science Foundation of Hubei Province (No. 2010CDA061).

Three-component reactions of ethyl 1-phenyl-3-trifloromethyl-5-[(triphenylphosphanylidene)amino]-4-carboxylate (iminophosphorane 2) with aromatic isocyanate and piperazine derivatives produced novel 1,4-[6,6'-(3-trifluoromethyl-pyrazolo[3,4-d]pyrimidinyl)]piperazines in the presence of EtONa in 55%~87% yields. The structures of synthetic compounds were confirmed by 1H NMR, IR, MS techniques and elemental analysis.

Key words: piperazine, pyrazolo[3,4-d]pyrimidine, multi-component reaction, synthesis