Chin. J. Org. Chem. ›› 2013, Vol. 33 ›› Issue (02): 378-382.DOI: 10.6023/cjoc201210031 Previous Articles     Next Articles



马梦林a,b, 黄剑彪a,c, 王玉良b, 陈淑华b, 陈华b   

  1. a 西华大学物理与化学学院 成都 610039;
    b 四川大学化学学院 教育部绿色化学重点实验室 成都 610064;
    c 上海大学理学院 上海200444
  • 收稿日期:2012-10-17 修回日期:2012-11-05 发布日期:2012-11-15
  • 通讯作者: 马梦林
  • 基金资助:

    国家自然科学基金(No. B020601);四川省自然科学重点基金(No. 07ZA109)资助项目.

Syntheses of 4-(1H)-Quinolones and the Brominated or Methoxy Substituted Derivatives

Ma Menglina,b, Huang Jianbiaoa,c, Wang Yuliangb, Chen Shuhuab, Chen Huab   

  1. a School of Physics and Chemistry, Xihua University, Chengdu 610039;
    b Key Laboratory of Green Chemistry and Technology of Ministry of Education, Faculty of Chemistry, Sichuan University, Chengdu 610064;
    c College of Science, Shanghai University, Shanghai 200444
  • Received:2012-10-17 Revised:2012-11-05 Published:2012-11-15
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. B020601), the Natural Science Foundation of Sichuan Province (No. 07ZA109).

A simple and new synthetic approach to 4-(1H)-quinolones was described. This method was started from ethyl 3,3-diethoxypropanoate and aniline via a synthetic sequence of preparation of key intermediate 3-(phenylimino)propionate and cyclization reaction. The brominated or methoxy substituted derivatives were synthesized by this new method as well.

Key words: 4(1H)quinolones, 3,3-diethoxypropanoate, synthetic method, cyclization