Chin. J. Org. Chem. ›› 2013, Vol. 33 ›› Issue (08): 1674-1685.DOI: 10.6023/cjoc201212050 Previous Articles     Next Articles



刘改枝a, 韩德恩a, 王鹏b, 刘宏民b   

  1. a 河南中医学院药学院 郑州 450046;
    b 郑州大学药学院 郑州 450001
  • 收稿日期:2012-12-30 修回日期:2013-02-05 出版日期:2013-08-25 发布日期:2013-02-22
  • 通讯作者: 刘改枝, 刘宏民;
  • 基金资助:

    河南中医学院博士基金(No. BSJJ2010-03)资助项目.

Synthesis Research Progress of Rofecoxib and Its Derivatives

Liu Gaizhia, Han Deena, Wang Pengb, Liu Hongminb   

  1. a Henan University of TCM, Zhengzhou 450046;
    b School of Pharmaceutical Science, Zhengzhou University, Zhengzhou 450001
  • Received:2012-12-30 Revised:2013-02-05 Online:2013-08-25 Published:2013-02-22
  • Supported by:

    Project supported by the Doctoral Research Foundation of Henan University of Traditional Chinese Medicine (No. BSJJ2010-03).

Rofecoxib is a novel non-steroidal anti-inflammatory drug, which is the representative of cyclooxygenase inhibitor. Taking rofecoxib would increase the risk of heart attack or stroke risk. Although rofecoxib withdrawal from the market due to cardiovascular risk, but its excellent analgesic and anti-inflammatory activity still has great research value and broad application prospect. Therefore, rofecoxib as a lead compound, has become a focus of research, from which researchers try to find good activity and little side effects rofecoxib derivatives. The research progress of rofecoxib and its derivatives is reviewed, including synthesis of rofecoxib and its derivatives.

Key words: rofecoxib, derivative, synthesis, research progress