Chin. J. Org. Chem. ›› 2013, Vol. 33 ›› Issue (08): 1655-1667.DOI: 10.6023/cjoc201301015 Previous Articles     Next Articles



刘敏a, 谭慧龙a, 刘治国a, 王维b, 曾文彬a   

  1. a 中南大学药学院 长沙 410013;
    b 中南大学湘雅三医院放射科 长沙 410013
  • 收稿日期:2013-01-08 修回日期:2013-02-22 发布日期:2013-03-07
  • 通讯作者: 曾文彬
  • 基金资助:

    国家自然科学基金(Nos. 30900377, 81271634);湖南省自然科学杰出青年基金(No. 12JJ1012);教育部新世纪优秀人才计划(No. NCET-10-0800)及教育部高等学校博士学科点专项科研基金(No. 20120162110070)资助项目.

Advances in Fluorescent Probes Based on the Small Molecules for Zn2+

Liu Mina, Tan Huilonga, Liu Zhiguoa, Wang Weib, Zeng Wenbina   

  1. a School of Pharmaceutical Sciences, Central South University, Changsha 410013;
    b Department of Radiology, Third Xiangya Hosipital of Central South University, Changsha 410013
  • Received:2013-01-08 Revised:2013-02-22 Published:2013-03-07
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 30900377, 81271634), the National Science Foundation for Distinguished Young Scholars of Hunan Province (No. 12JJ1012), the Education for New Century Excellent Talents (No. NCET-10-0800) and the Research Fund for the Doctoral Program of Higher Education (No. 20120162110070).

Zinc ion (Zn2+) plays an essential role in many physiological processes of the organism, such as brain activities, gene transcription and immune function, as well as some pathological processes and so on, therefore selective recognition and detection of Zn2+ are of important biological significance. Fluorescence technology has unique advantages such as high selectivity, sensitivity, low cost, real-time and in situ monitoring, thus it has become one of the most important sensing technologies for zinc ion and a hot topic area in recent years to imaging Zn2+ in cells. Herein, the latest progresses in the last 10 years of fluorescent molecular probes based on the small molecules for Zn2+ are reviewed. These important fluorescent probes are classified according to three different mechanisms action (PET, ICT and FRET). The designs of molecular structure, sensing mechanism and biological applications of these probes are introduced. In addition, the structure and property relationships are elucidated. Finally, the problems and the developing trends in this field are also discussed.

Key words: zinc ions, fluorescence, molecular probe, small molecule