Chin. J. Org. Chem. ›› 2015, Vol. 35 ›› Issue (1): 100-108.DOI: 10.6023/cjoc201408004 Previous Articles     Next Articles



杨亚喆, 林大勇, 傅翠蓉, 邹小毛   

  1. 南开大学元素有机化学研究所 元素有机化学国家重点实验室 天津化学化工协同创新中心 天津 300071
  • 收稿日期:2014-08-03 修回日期:2014-09-26 发布日期:2014-10-13
  • 通讯作者: 邹小毛
  • 基金资助:

    国家自然科学基金(Nos. 20772067, 21472102)资助项目.

Synthesis and Biological Activity Evaluation of Novel Pyrazole Oxime Ether Derivatives Containing Chlorothiazole Group and Pyrimidine Rings

Yang Yazhe, Lin Dayong, Fu Cuirong, Zou Xiaomao   

  1. State Key Laboratory of Elemento-Organic Chemistry, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Institute of Elemento-Organic Chemistry, Nankai University, Tianjin 300071
  • Received:2014-08-03 Revised:2014-09-26 Published:2014-10-13
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 20772067, 21472102).

On the basis of our previous work, in order to seeking for novel compounds with bioactivities to settle for the resistance problem, two series of novel pyrazole oxime ether derivatives have been designed and synthesized containing chlorothiazole group and pyrimidine rings applying the bioisosterism. Their structures were determined by 1H NMR, IR, elemental analysis and MS, and their bioactivities were performed. Nearly half of the target compounds of series A with chlorothiazole group exhibited good insecticidal activity against culex pipiens pallens (100%, 5 mg·L-1), several compounds of series A showed good activity against Aphis laburni Kaltenbach (100%, 200 mg/L) and Tetranychus cinnabarinus (100%, 200 mg/L), and the compounds of series B with pyrimidine rings exhibited certain fungicidal activity.

Key words: pyrazole oxime, chlorothiazole, pyrimidine rings, synthesis, bioactivity